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KMID : 1161420100130010179
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Journal of Medicinal Food
2010 Volume.13 No. 1 p.179 ~ p.188
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Protective Role of Ginkgo biloba Against Hepatotoxicity and Nephrotoxicity in Uranium-Treated Mice
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Yapar Kursad
Cavusoglu Kultigin
Oruc Ertan
Yalcin Emine
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Abstract
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The aim of the present study was to investigate the protective role of Ginkgo biloba leaf extract against uranium (U)-induced toxicity in Swiss albino mice. The mice were randomly divided into six groups, each consisting of six animals: Group I (control) received tap water alone, Group II received U at a dose of 5?mg/kg of body weight, Group III received G. biloba at a dose of 50?mg/kg of body weight, Group IV received G. biloba at a dose of 150?mg/kg of body weight, Group V received G. biloba (50?mg/kg of body weight) and U (5?mg/kg of body weight), and Group VI received G. biloba (150?mg/kg of body weight) and U (5?mg/kg of body weight) by oral gavage for 5 days. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine levels were determined to assess liver and kidney function, respectively. Also, liver and kidney samples were taken for the determination of tissue malondialdehyde (MDA) and reduced glutathione (GSH) levels, and histopathological changes in liver and kidneys were investigated. The results indicated that there was a significant increase (P?
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KEYWORD
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antioxidant enzymes, Ginkgo biloba, pathology, serum biochemistry, uranium toxicity
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